Larissa J Strath

Larissa J Strath,

RES AST PROF

Department: MD-HOBI-GENERAL
Business Phone: (352) 273-5971
Business Email: larissastrath@ufl.edu

About Larissa J Strath

My research is largely focused on the effects that dietary composition has on the modulation of the pain experi ence, specifically through epigenetic and immune mechanisms. With that in mind, I have dealt with a variety of painful conditions and pathologies ( i.e. chronic low back pain, knee osteoarthritis, fibromyalgia etc.) and understanding of nutrient status and their effects on the system at a variety of ages (i.e. inflammation and oxidative stress). My areas of expertise include nutritional biochemistry, pain medicine, neuroscience, and epigenetics. My experience cross es borders, having basic science, clinical science, and epidemiological opportunities over the course of my doctoral training. My PhD work employed the use of nutritive model s to identify factors that may contribute substantially to the development and per petuation of chronic pain , with an emphasis on sex, gender and racial disparities therein . I have extensive experimental skills in the acquisition, protocol design and execution, and analyses of a variety of nutrition – based models (i.e. diet pattern analy sis, nutrient analysis, Dietary Inflammatory Index) in humans and rodents. I have advanced theoretical and practical skills in designing , i mplementing and analyzing various neuroscience – based pain – related measures. My doctoral training gave me extensive e xperience in the use of dynamic quantitative sensory testing, as well as experience investigating blood – based inflammatory and oxidative stress mediators and standardized measures of psychosocial assessment. Over my career, I have used several statistical methods including multivariate regressions, modified Poisson regressions, analysis of variance (ANOVA), as well as mediation and moderation analyses to understand these data. My dissertation work has resulted in the publication of 4

first – author, experime nt – based manuscripts, 4 first author review articles, and 1 collaborative manuscript related to HIV and chronic pain. My current research interests center around understanding the nutriepigenomic mechanisms that contribute to the pain experience observed i n various types of acute and chronic pain. Additionally, my future research interests include how the nutriepigenomic/pain relationship impacts cognition and the development of neurological diseases such as Alzheimer’s Disease over time. At the Universit y of Florida (UF) , Dr. Cruz – Almeida ’s mentorship has afforded me a unique opportunity to employ my research skills related to nutri – biological and psycho social pain phenotyping in a an aging population and to expand the existing body of literature specific to epigenetic and neuroscientific pain – related mechanisms

Accomplishments

Junior Investigator of the Year for Pain in Older Persons
2023 · International Association for the Study of Pain
Gregg Steele Outstanding Graduate Student in Behavioral Neuroscience
2021 · The University of Alabama at Birmingham

Teaching Profile

Courses Taught
2023
DEN6251 Clin Manage Dent Pain
Teaching Philosophy
My teaching philosophy rests on three primary objectives. First, I want my students to learn the fundamental content of the course I am teaching. Second, I believe in orienting students to both the science and application of a discipline. Within the biom edical field, a disconnect often exists between professionals who primarily conduct research and those who primarily provide patient care. Providing students with a scientific perspective (i.e., research, theory), as well as the application perspective (i .e., how can this information be used in the real world) of the content of the course is an important step in bridging this gap. Furthermore, I believe is important for doctoral – level students to develop an appreciation and understanding of both pre – clinic al and clinical research and the importance of continuous cross – talk (i.e., translational research). Finally, and most importantly, my aim is to teach critical thinking skills which will transfer across domains. In any career, the ability to critically thi nk is imperative. However, research suggests that numerous adults in our society, including college graduates, employ flawed thinking. In a world where an enormous amount of information is a click away via the internet, students must not be passive observ ers but know how to judge, analyze, and synthesize the available information. I also strive to provide students with opportunities in which they can become an active agent in their own learning process through the use of writing, class/group discussion, an d questioning

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9616-0177

Areas of Interest
  • Aging
  • Alzheimer’s Disease
  • Chronic Pain
  • Clinical Nutrition
  • Clinical Translational Neuroscience
  • Epigenetics
  • Immune-Mediated Disease
  • Interventional pain medicine
  • Neuroimmune interactions in Neurodegenerative diseases
  • Nutrition and Wellness

Publications

2024
Epigenetic Aging: A Socio-Biological Link to Chronic Pain?
The journal of pain. 25(2):572-573 [DOI] 10.1016/j.jpain.2023.11.007. [PMID] 37984508.
2024
Food insecurity is associated with chronic pain and high-impact chronic pain in the USA
Public Health Nutrition. 27(1) [DOI] 10.1017/s1368980023002732.
2024
Perspective: Promoting Healthy Aging through Nutrition: A Research Centers Collaborative Network Workshop Report.
Advances in nutrition (Bethesda, Md.). 15(4) [DOI] 10.1016/j.advnut.2024.100199. [PMID] 38432592.
2024
Race-specific associations: inflammatory mediators and chronic low back pain.
Pain. [DOI] 10.1097/j.pain.0000000000003154. [PMID] 38323608.
2024
Socioeconomic Status, Knee Pain, and Epigenetic Aging in Community-Dwelling Middle-to-Older Age Adults.
The journal of pain. 25(2):293-301 [DOI] 10.1016/j.jpain.2023.06.002. [PMID] 37315728.
2023
A Brief Overview: Sex Differences in Prevalent Chronic Musculoskeletal Conditions.
International journal of environmental research and public health. 20(5) [DOI] 10.3390/ijerph20054521. [PMID] 36901530.
2023
Altered response to Toll-like receptor 4 activation in fibromyalgia: A low-dose, human experimental endotoxemia pilot study.
Brain, behavior, & immunity – health. 34 [DOI] 10.1016/j.bbih.2023.100707. [PMID] 38020479.
2023
Epigenetic age acceleration mediates the relationship between neighborhood deprivation and pain severity in adults with or at risk for knee osteoarthritis pain
Social Science & Medicine. 331 [DOI] 10.1016/j.socscimed.2023.116088. [PMID] 37473540.
2023
Vitamin D Metabolism Genes Are Differentially Methylated in Individuals with Chronic Knee Pain.
Lifestyle genomics. 16(1):98-105 [DOI] 10.1159/000529823. [PMID] 36854277.
2022
Accelerated Epigenetic Aging Mediates the Association between Vitamin D Levels and Knee Pain in Community-Dwelling Individuals.
The journal of nutrition, health & aging. 26(4):318-323 [DOI] 10.1007/s12603-022-1758-z. [PMID] 35450986.
2022
Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain.
Frontiers in neuroscience. 16 [DOI] 10.3389/fnins.2022.882322. [PMID] 36117614.
2022
Dietary Inflammatory Index (DII) is Associated with Movement-Evoked Pain Severity in Adults with Chronic Low Back Pain: Sociodemographic Differences.
The journal of pain. 23(8):1437-1447 [DOI] 10.1016/j.jpain.2022.03.237. [PMID] 35417792.
2022
Epigenetic Aging Mediates the Association between Pain Impact and Brain Aging in Middle to Older Age Individuals with Knee Pain.
Epigenetics. 17(13):2178-2187 [DOI] 10.1080/15592294.2022.2111752. [PMID] 35950599.
2022
Racial Differences in 25-Hydroxy Vitamin D and Self-Reported Pain Severity in a Sample of Individuals Living with Non-Specific Chronic Low Back Pain.
Journal of pain research. 15:3859-3867 [DOI] 10.2147/JPR.S386565. [PMID] 36514480.
2022
Racial Differences in Pain, Nutrition, and Oxidative Stress.
Pain and therapy. 11(1):37-56 [DOI] 10.1007/s40122-022-00359-z. [PMID] 35106711.
2022
Relationship between diet and relative risk of pain in a cross-sectional analysis of the REGARDS longitudinal study.
Pain management. 12(2):168-179 [DOI] 10.2217/pmt-2021-0048. [PMID] 34431328.
2020
<p>Sex and Gender are Not the Same: Why Identity Is Important for People Living with HIV and Chronic Pain</p>
Journal of Pain Research. Volume 13:829-835 [DOI] 10.2147/jpr.s248424.
2020
Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation.
Pain and therapy. 9(2):487-498 [DOI] 10.1007/s40122-020-00200-5. [PMID] 33085012.
2020
The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis.
Pain medicine (Malden, Mass.). 21(1):150-160 [DOI] 10.1093/pm/pnz022. [PMID] 30865775.
2018
Intersectional health-related stigma in persons living with HIV and chronic pain: implications for depressive symptoms.
AIDS care. 30(sup2):66-73 [DOI] 10.1080/09540121.2018.1468012. [PMID] 29848042.
2017
The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury.
Scandinavian journal of pain. 17:316-324 [DOI] 10.1016/j.sjpain.2017.08.009. [PMID] 28927908.

Grants

May 2023 ACTIVE
Pain and Nutrition in Dementia and Alzheimers PANDA
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2019 ACTIVE
OoR Matching Support for CTSI
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS

Education

Post Doctoral Associate
2021-2023 · University of Florida
Doctor of Philosophy – Behavioral Neuroscience
2016-2021 · The University of Alabama at Birmingham
Bachelor of Science – Biology: Pre-Med; Minor: Chemistry
2012-2016 · Faulkner University

Contact Details

Phones:
Business:
(352) 273-5971
Emails:
Addresses:
Business Mailing:
PO Box 100147
GAINESVILLE FL 32610
Business Street:
1889 Museum Rd, Suite 7000
GAINESVILLE FL 32611