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Health Outcomes & Biomedical Informatics

College of Medicine

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Keith E Muller

Keith E Muller, Ph.D.

Professor

Department: MD-HOP-GENERAL
Business Phone: (352) 294-5957
Business Email: kmuller@ufl.edu

About Keith E Muller

Professor Muller has NIH funding from NIGMS, NLM, and NCATS. His journal publications are split roughly equally between scientific collaborations and biostatistical methodology developments. In addition, Professor Muller is the first author of two current books on the theory and practice of linear models.

Professor Muller serves as co-principal investigator of 9R01GM121081-05, “Methods and Software for Lifecourse Epidemiology Data and Sample Size Analysis” funded by NIH/NIGMS, 08/15/2016-06/30/2020, as a continuation of 1R01DE020832-01A1. Co-principal investigators are Dr. D. H. Glueck (UCD) and Dr. D. Dabelea (UCD). Dr. Muller (UF) and Dr. D. H. Glueck (UCD) are co-PI of 1R25GM111901-01, “A Master Course on Power for Multilevel and Longitudinal Health Behavior Studies,” funded by NIH/OBSS and NIGMS, 08/25/2014-06/30/2018, and also 1G13LMO11879-01, “Guidebook to Power and Sample Size for linear models,” funded by NLM/NIH, 12/01/2014-11/30/2016.

Research Profile

Professor Muller’s current research centers on power and sample size for multilevel and longitudinal designs, especially with trajectories as predictors. He and colleagues also pursue advances in adaptive designs and High Dimension, Low Sample Size (more variables than participants).

Areas of Interest
  • Biostatistics
  • Health outcomes research
  • Statistical methods

Publications

2019
Calculating Power for the General Linear Multivariate Model With One or More Gaussian Covariates.
Communications in statistics: theory and methods
2019
The Wellness Incentive and Navigation intervention improved health-related quality of life among Medicaid enrollees: A randomized pragmatic clinical trial.
Health services research
2019
Power and Sample Size for Fixed-Effects Inference in Reversible Linear Mixed Models.
The American statistician
2019
Exploring the Role of Executive Functioning Capacity in Patient Activation and Health Outcomes Among Medicaid Members With Multiple Comorbidities.
Medical care research and review : MCRR
2019
On the Distribution of Summary Statistics for Missing Data.
Communications in statistics: theory and methods
2018
Trajectories of Nevus Development From Age 3 to 16 Years in the Colorado Kids Sun Care Program Cohort.
JAMA dermatology
2018
Internal pilot design for balanced repeated measures.
Statistics in medicine
2018
Assessing the reliability of the short form 12 (SF-12) health survey in adults with mental health conditions: a report from the wellness incentive and navigation (WIN) study.
Health and quality of life outcomes
2018
Comparing methods of misclassification correction for studies of adolescent alcohol use.
The American journal of drug and alcohol abuse
2018
Development of a Virtual Radiation Oncology Clinic for Training and Simulation of Errors in the Radiation Oncology Workflow
Practical Radiation Oncology
2017
Definitive chemoradiation for locoregional recurrences of esophageal cancer after primary curative treatment.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
2016
Improving Adolescent Health Risk Assessment: A Multi-method Pilot Study.
Maternal and child health journal
2016
Multivariate test power approximations for balanced linear mixed models in studies with missing data.
Statistics in medicine
2016
The effects of experimentally manipulated social status on acute eating behavior: A randomized, crossover pilot study.
Physiology & behavior
2015
Adaptive designs for comparative effectiveness research trials.
Clinical research and regulatory affairs
2015
Determinants of First-Time Cancer Examinations in a Rural Community: A Mechanism for Behavior Change.
American journal of public health
2015
Quality of Care for Chronic Conditions Among Disabled Medicaid Enrollees: An Evaluation of a 1915 (b) and (c) Waiver Program.
Medical care
2015
Recommendations for choosing an analysis method that controls Type I error for unbalanced cluster sample designs with Gaussian outcomes.
Statistics in medicine
2015
The wellness incentives and navigation project: design and methods.
BMC health services research
2014
The Effects of Cognition On Patient Activation and Subsequent Patient-Reported Outcomes Among Patients With Co-Occurring Physical and Mental Health Disorders
Quality of Life Research
2014
Separability tests for high-dimensional, low sample size multivariate repeated measures data.
Journal of applied statistics
2014
Reducing decision errors in the paired comparison of the diagnostic accuracy of screening tests with Gaussian outcomes.
BMC medical research methodology
2014
Power calculation for overall hypothesis testing with high-dimensional commensurate outcomes.
Statistics in medicine
2014
GLIMMPSE Lite: calculating power and sample size on smartphone devices.
PloS one
2014
Health literacy: a pathway to better oral health.
American journal of public health
2014
Drug-eluting stents may not reduce target lesion revascularization in cardiac allograft vasculopathy.
Journal of interventional cardiology
2014
Kronecker product linear exponent AR(1) correlation structures for multivariate repeated measures.
PloS one
2014
Analytic methods for individually randomized group treatment trials and group-randomized trials when subjects belong to multiple groups.
Statistics in medicine
2013
Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
The Journal of nutrition
2013
Two-Step Hypothesis Testing When the Number of Variables Exceeds the Sample Size.
Communications in statistics: Simulation and computation
2013
The burden of chronic diseases in a rural North Florida sample.
BMC public health
2013
Selecting a sample size for studies with repeated measures.
BMC medical research methodology
2013
Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
PloS one
2013
Increasing screening intentions for oral and pharyngeal cancer.
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
2013
Fractional anisotropy distributions in 2- to 6-year-old children with autism.
Journal of intellectual disability research : JIDR
2013
Disparities in knowledge of mouth or throat cancer among rural Floridians.
The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association
2013
Confidence regions for repeated measures ANOVA power curves based on estimated covariance.
BMC medical research methodology
2013
: Online Power Computation for Linear Models with and without a Baseline Covariate.
Journal of statistical software
2013
Glimmpse: Online Power Computation for Linear Models With and Without a Baseline Covariate
Journal of Statistical Software
2012
Adaptive trial designs: a review of barriers and opportunities.
Trials
2012
Global hypothesis testing for high-dimensional repeated measures outcomes.
Statistics in medicine
2012
Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women.
The Journal of nutrition
2012
Psychosocial factors associated with mouth and throat cancer examinations in rural Florida.
American journal of public health
2011
Avoiding bias in mixed model inference for fixed effects.
Statistics in medicine
2011
Quantitative imaging test approval and biomarker qualification: interrelated but distinct activities.
Radiology
2010
Using scientifically and statistically sufficient statistics in comparing image segmentations.
Statistics and its interface
2010
Real longitudinal data analysis for real people: building a good enough mixed model.
Statistics in medicine
2010
Probabilities for separating sets of order statistics.
Statistics
2010
Diagnostic value of noninvasive combined fluorine-18 labeled fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography enterography in active Crohn’s disease.
Inflammatory bowel diseases
2010
Combining an Internal Pilot with an Interim Analysis for Single Degree of Freedom Tests.
Communications in statistics: theory and methods
2010
Approximating the Geisser-Greenhouse sphericity estimator and its applications to diffusion tensor imaging.
Statistics and its interface
2010
A linear exponent AR(1) family of correlation structures.
Statistics in medicine
2010
Closure times measured by the platelet function analyzer PFA-100 are longer in neonatal blood compared to cord blood samples.
Neonatology
2009
Bias in trials comparing paired continuous tests can cause researchers to choose the wrong screening modality.
BMC medical research methodology
2009
Powerlib: Sas/Iml Software for Computing Power in Multivariate Linear Models
Journal of Statistical Software
2009
POWERLIB: SAS/IML Software for Computing Power in Multivariate Linear Models.
Journal of statistical software
2008
An R2 statistic for fixed effects in the linear mixed model.
Statistics in medicine
2008
Exact calculations of average power for the Benjamini-Hochberg procedure.
The international journal of biostatistics
2008
Expected Power for the False Discovery Rate with Independence.
Communications in statistics: theory and methods
2008
Fast Computation by Block Permanents of Cumulative Distribution Functions of Order Statistics from Several Populations.
Communications in statistics: theory and methods
2008
GLUMIP 2.0: Software for Planning Internal Pilots.
Journal of statistical software
2008
GLUMIP 2.0: SAS/IML Software for Planning Internal Pilots
Journal of Statistical Software
2008
The Ugly, the Bad, and the Good of Missing and Dropout Data in Analysis and Sample Size Selection
American Journal of Primatology
2007
Statistical tests with accurate size and power for balanced linear mixed models.
Statistics in medicine
2007
Practical Methods for Bounding Type I Error Rate with an Internal Pilot Design.
Communications in statistics: theory and methods
2007
Effects of home access and availability of alcohol on young adolescents’ alcohol use.
Addiction (Abingdon, England)
2007
Internal pilots for a class of linear mixed models with Gaussian and compound symmetric data.
Statistics in medicine
2006
Analytic, Computational, and Approximate Forms for Ratios of Noncentral and Central Gaussian Quadratic Forms.
Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
2006
Comparison of calcification specificity in digital mammography using soft-copy display versus screen-film mammography.
AJR. American journal of roentgenology
2005
Analyzing attributes of vessel populations.
Medical image analysis
2005
Assessment of real-time 3D visualization for cardiothoracic diagnostic evaluation and surgery planning.
Journal of digital imaging
2005
Comparison of human and automatic segmentations of kidneys from CT images.
International journal of radiation oncology, biology, physics
2005
The effects of gray scale image processing on digital mammography interpretation performance.
Academic radiology
2004
A parametric model for studying organism fitness using step-stress experiments.
Biometrics
2004
Abnormal vessel tortuosity as a marker of treatment response of malignant gliomas: preliminary report.
Technology in cancer research & treatment
2004
EXACT DISTRIBUTIONS OF INTRACLASS CORRELATION AND CRONBACH’S ALPHA WITH GAUSSIAN DATA AND GENERAL COVARIANCE.
Psychometrika
2003
Properties of internal pilots with the univariate approach to repeated measures.
Statistics in medicine
2003
Deformable M-Reps for 3D Medical Image Segmentation.
International journal of computer vision
2003
Diagnostic accuracy of digital mammography in patients with dense breasts who underwent problem-solving mammography: effects of image processing and lesion type.
Radiology
2003
A new method for choosing sample size for confidence interval-based inferences.
Biometrics
2003
Adjusting power for a baseline covariate in linear models.
Statistics in medicine
2002
Augmented reality guidance for needle biopsies: an initial randomized, controlled trial in phantoms.
Medical image analysis
2002
Improved approximate confidence intervals for the mean of a log-normal random variable.
Statistics in medicine
2002
Interpretation of digital mammograms: comparison of speed and accuracy of soft-copy versus printed-film display.
Radiology
2002
Thresholds for human detection of patient setup errors in digitally reconstructed portal images of prostate fields.
International journal of radiation oncology, biology, physics
2001
Controlling test size while gaining the benefits of an internal pilot design.
Biometrics
2001
Improving the detection of simulated masses in mammograms through two different image-processing techniques.
Academic radiology
2001
Linear equality constraints in the general linear mixed model.
Biometrics
2001
On the Expected Values of Sequences of Functions.
Communications in statistics: theory and methods
2001
Symbolic description of intracerebral vessels segmented from magnetic resonance angiograms and evaluation by comparison with X-ray angiograms.
Medical image analysis
2000
Tests for gaussian repeated measures with missing data in small samples.
Statistics in medicine
2000
Some Distributions and Their Implications for an Internal Pilot Study With a Univariate Linear Model.
Communications in statistics: theory and methods
2000
Properties of Doubly-Truncated Gamma Variables.
Communications in statistics: theory and methods
2000
Radiologists’ preferences for digital mammographic display. The International Digital Mammography Development Group.
Radiology
1999
Comparison of computer workstation with light box for detecting setup errors from portal images.
International journal of radiation oncology, biology, physics
1999
Effect of display luminance on the feature detection rates of masses in mammograms.
Medical physics
1999
Exact test size and power of a Gaussian error linear model for an internal pilot study.
Statistics in medicine
1999
Registration of 3D cerebral vessels with 2D digital angiograms: clinical evaluation.
Academic radiology
1998
A New Approximation for the Pillai-Bartlett Trace under
Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America
1998
APPROXIMATING POWER OF THE UNCONDITIONAL TEST FOR CORRELATED BINARY PAIRS.
Communications in statistics: Simulation and computation
1998
Contrast limited adaptive histogram equalization image processing to improve the detection of simulated spiculations in dense mammograms.
Journal of digital imaging
1997
BIAS IN LINEAR MODEL POWER AND SAMPLE SIZE DUE TO ESTIMATING VARIANCE.
Communications in statistics: theory and methods
1997
Does intensity windowing improve the detection of simulated calcifications in dense mammograms?
Journal of digital imaging
1997
Hepatic enhancement and metastatic lesion conspicuity on CT scans: influence of intravenous glucagon and oral CT contrast material.
Radiology
1997
Proton MR spectroscopy of squamous cell carcinoma of the extracranial head and neck: in vitro and in vivo studies.
AJNR. American journal of neuroradiology
1997
THE DISTRIBUTION OF COOK’S D STATISTIC.
Communications in statistics: theory and methods
1997
The effect of intensity windowing on the detection of simulated masses embedded in dense portions of digitized mammograms in a laboratory setting.
Journal of digital imaging
1996
BIAS IN LINEAR MODEL POWER AND SAMPLE SIZE CALCULATION DUE TO ESTIMATING NONCENTRALITY.
Communications in statistics: theory and methods
1995
A review of therapeutic studies of idiopathic membranous glomerulopathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation
1995
Computing Confidence Bounds for Power and Sample Size of the General Linear Univariate Model.
The American statistician
1995
Interpretation time of serial chest CT examinations with stacked-metaphor workstation versus film alternator.
Radiology
1995
Introduction to perceptual linearization of video display systems for medical image presentation.
Journal of digital imaging
1995
A COMPARISON OF POWER APPROXIMATIONS FOR SATTERTHWAITE’S TEST.
Communications in statistics: Simulation and computation
1994
A method for determination of optimal image enhancement for the detection of mammographic abnormalities.
Journal of digital imaging
1993
A formal curriculum in breast imaging for radiology residents.
Investigative radiology
1993
Interpretation of CT studies: single-screen workstation versus film alternator.
Radiology
1993
Portal film enhancement: technique and clinical utility.
International journal of radiation oncology, biology, physics
1992
Increasing scientific power with statistical power.
Neurotoxicology and teratology
1992
Power Calculations for General Linear Multivariate Models Including Repeated Measures Applications.
Journal of the American Statistical Association
1983
Design and analysis issues and strategies in psychophysiological research.
Psychophysiology
1981
Effects of age and body lead burden on CNS function in young children. I. slow cortical potentials.
Electroencephalography and clinical neurophysiology
1980
Evaluating the effects of air pollution on sensitive subjects.
American journal of public health

Grants

Nov 2017 – Oct 2018
Safety of Direct Acting Antiviral Medications for Hepatitis C
KAISER FOU RESEARCH INSTITUTE ·
Aug 2016 ACTIVE
Methods and Software for Lifecourse Epidemiology Data and Sample Size Analysis
UNIVERSITY OF COLORADO DENVER · Principal Investigator
Jan 2016 ACTIVE
Prioritize Study
PATIENT-CENTERED OUTCOMES RES INST ·
Sep 2014 – Sep 2018
Power and Sample Size for Multilevel and Longitudinal
NATL INST OF HLTH NLM · Principal Investigator
Aug 2014 – Jun 2020
A Master Course on Power for Multilevel and Longitudinal Health Behavior Studies
NATL INST OF HLTH NIGMS · Principal Investigator
Oct 2011 ACTIVE
HCV-TARGET Primary Operating Project with subprojects
UF DIV OF SPONSORED RESEARCH · Project Manager
Aug 2011 – Feb 2020
Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
NATL INST OF HLTH NICHD · Project Manager
Dec 2010 – Nov 2015
Multilevel and Longitudinal Study Sample Size Tools
NATL INST OF HLTH · Principal Investigator
Sep 2010 – Jun 2017
Substance abuse and immunity in HIV+ adolescents by syst
NATL INST OF HLTH NIDA · Project Manager

Contact Details

Phones:
Business:
(352) 294-5957
Emails:
Business:
kmuller@ufl.edu